Postgrad Med. Moreover, if Lamictal does impact weight, it’s most likely to induce weight loss (rather than cause weight gain). How Doctors Choose Between an Atypical and Typical Antipsychotic. The phase IV clinical study is created by eHealthMe based on reports of 63,927 people who have side effects when taking Lamictal from the FDA, and is updated regularly. Did you track calories and physical activity throughout Lamictal treatment to verify that the weight change you experienced wasn’t simply due to altered energy intake or expenditure? The ideas, procedures, and suggestions contained within this work are not intended as a substitute for consulting with a medical doctor. Find everything you need to know about Lamictal (Lamotrigine), including what it is used for, warnings, reviews, side effects, and interactions. As you’ll read, none of the available data indicate that Lamictal causes weight gain. It's also used as a mood stabilizer in bipolar disorder.. Note: If you experienced substantial unwanted weight change while using Lamictal, and none of the above-mentioned weight management strategies are helpful, you may want to discuss the idea of Lamictal withdrawal and/or switching to another medication – with your doctor. You, as a reader of this website, are totally and completely responsible for your own health and healthcare. On the other hand, if you lost weight while taking Lamictal, you may end up gaining weight in withdrawal. In a small clinical trial involving 40 people conducted in 2006, researchers randomly assigned the participants to receive either Lamictal or a placebo for up to 26 weeks. Always feeling tired? The good news for prospective Lamictal users is that, according to research, Lamictal is unlikely to cause significant weight change – and if weight change does occur, it’s most likely to be modest weight loss. Paul Reynolds. Does Lamictal (Lamotrigine) Cause or Treat Anxiety? It probably won't affect your weight much at all. Common side effects of Lamictal include: ataxia, skin rash, headache, insomnia, and nausea. Children's weight should be checked and the dose reviewed as weight changes with growth occur. Lexapro (Escitalopram) vs Zoloft (Sertraline): Extensive Comparison. When used properly it can be very effective for calming the muscle spasms and convulsions that accompany most epileptic episodes. People with type 2 diabetes are often encouraged to lose weight, as this can help return their blood sugar to normal levels. ... diarrhea, headache, general pain, runny nose, unusual weight loss, trouble sleeping or insomnia, menstrual pain, … doi:10.4088/jcp.v67n0212. Ⓒ 2021 About, Inc. (Dotdash) — All rights reserved. is “weight neutral”), and some evidence supports the idea that Lamictal may cause weight loss. While more research is needed to determine if Lamictal might be beneficial as a weight-loss treatment, current research suggests that the medication may not cause significant weight loss that is common with some other bipolar medications. sought to determine the effect of frequently-prescribed antiepileptic medications on the body weights of users. For this reason, you might end experiencing much more substantial weight change on Lamictal than what’s considered “average.”. If you're concerned that taking the medication Lamictal (lamotrigine) may cause you to gain weight, there's good news. Variables that may be most likely to influence weight change among Lamictal users include: baseline weight (body weight prior to using Lamictal); adjunct substance use; Lamictal dose; duration of Lamictal use; prior medication use; and/or lifestyle/genetics of the user. Seroquel (Quetiapine) Drug Warnings and Side Effects, What to Know About Depakote Before You Start Taking It, Recovering from an Eating Disorder When You Live in a Larger Body, Daily Tips for a Healthy Mind to Your Inbox, Lamotrigine in the treatment of binge-eating disorder with obesity: a randomized, placebo-controlled monotherapy trial, Management of bipolar depression with lamotrigine: an antiepileptic mood stabilizer, Prescribing Information. Aa. – and obese users appear to lose more weight than non-obese users. Pharmacology, adverse reactions, warnings and side effects. Weight change associated with antiepileptic drugs. A single-center, double-blind, placebo-controlled evaluation of lamotrigine in the treatment of obesity in adults. Bowden, Asnis, Ginsberg, et al. Data for the retrospective analysis was derived from multiple double-blind, placebo-controlled, 18-month trials testing lamotrigine and lithium for the management of bipolar disorder. Can People of Higher Weights Be Anorexic? In the event that you experience weight change (gain or loss) while using Lamictal, included below is a list of possible reasons for that change. Sign up for our newsletter and get it free. for the lamotrigine recipients, and -1.2 lbs. If you experience substantial weight change from Lamictal , share this reaction with a medical doctor. Therefore, it is important that the dosing recommendations be followed closely. 2006: A single-center, double-blind, placebo-controlled evaluation of lamotrigine in the treatment of obesity in adults. The drug seems ineffective in the treatment of current rapid-cycling, acute mania, or acute depression in bipolar disorder. To help others fully understand the details associated with your Lamictal use, mention things like: how long you’ve used Lamictal; your Lamictal dosage; whether you use other substances with Lamictal; and whether you are currently underweight, overweight, or obese. In clinical trials, less than 5 percent of those taking Lamictal gained weight. ... itchiness, runny nose, cough, nausea, indigestion, abdominal pain, weight loss, missed or painful menstrual periods, and vaginitis. For example, several of them increase your blood sugar level, which can lead to weight gain. After a week and a half, I had to stop taking it. Guerdjikova AI, McElroy SL, Welge JA, Nelson E, Keck PE, Hudson JI. over a 4-month span. Based upon available medical research, Lamictal is likely to have no clinically significant effect on body weight. Int Clin Psychopharmacol. Favs List. In the first clinical trials involving the drug, 5% of adults with epilepsy lost weight while taking Lamictal, while between 1% and 5% of patients with bipolar I disorder gained weight while on the drug. The researchers didn't disclose how much weight the patients gained or lost. Certain mood stabilizers commonly used in bipolar disorder—specifically, lithium and Depakote (valproate)—carry a high risk of weight gain., In addition, the atypical antipsychotic medications Clozaril (clozapine) and Zyprexa (olanzapine) tend to cause significant weight gain in people taking them. Another study, this one in 2009, considered Lamictal as a treatment for binge-eating disorder. That study included 51 people with the condition—26 of them received Lamictal, while 25 received a placebo. – whereas weight gain might be caused by: somnolence, decreased metabolic rate, and/or appetite … Lamictal also has been studied as a possible treatment for obesity in people without epilepsy or bipolar disorder. lamotrigine). (6.1 kg) with lithium treatment; and weight loss of 1.32 lbs. Those taking Lamictal lost more weight than those on the placebo (about 2.5 pounds versus about one-third of a pound), and they did have significant improvements in their blood sugar and cholesterol lab test results. – and obese users appear to lose more weight than non-obese users. Taken in excess, though, this benefit can turn harmful and can actually cause a person to lose control of their muscle function entirely. If anything, you're more likely to lose weight because of Lamictal than to gain weight, but either way, the changes will probably be pretty small. A proposed method of action for Lamictal is that it suppresses the release of glutamate and aspartate, two of the dominant excitatory neurotransmitters of the central nervous system (CNS) which gives it the effect of a CNS depressant. 2006;163(7):1199–1201. LAMICTAL prescription and dosage sizes information for physicians and healthcare professionals. assessed the effect of lamotrigine and lithium on body weight of obese and non-obese patients with type-1 bipolar disorder. 2006: Effects of lamotrigine and lithium on body weight during maintenance treatment of bipolar I disorder. If anything, you're more likely to lose weight because of Lamictal than to gain weight, but either way, the changes will probably be pretty small. This site uses Akismet to reduce spam. Moreover, if Lamictal does impact weight, it’s most likely to induce weight loss (rather than cause weight gain). Data from the study revealed no changes in body weight or BMI associated with lamotrigine treatment – regardless of whether administered as a standalone or adjunct (with valproate, antipsychotics, lithium or antidepressants). ... • loss of memory . It was concluded that lamotrigine was safe, effective, and well-tolerated by patients. Understand that most Lamictal users do not experience clinically-significant weight change (characterized by body weight change of at least 7% from baseline). Of the 1800 trial participants, 827 received lamotrigine as a monotherapy or adjunct for an 18-month duration. Learn from their experiences about effectiveness, side effects and cost. caused weight gain (it did get me off the alprazolam though! Sachs, Bowden, Calabrese, et al. Those taking Lamictal lost, on average, a little more than 10 pounds. © 2013-2019 | Privacy Policy | Legal Notice | Affiliate Disclosure, Lithium & Weight Gain: How Much? The findings in lamictal and vyvanse weight loss this group, increasing the risk for the analysis. Our guide offers strategies to help you or your loved one live better with bipolar disorder. Notify me of followup comments via e-mail. Rapid weight loss for type 2 diabetes may harm some. Lamictal (lamotrigine) Tablets. Steven Gans, MD is board-certified in psychiatry and is an active supervisor, teacher, and mentor at Massachusetts General Hospital. Learn how your comment data is processed. Non-obese patients exhibited: weight loss of 1.1 lbs. All matters regarding your health require medical supervision. Authors briefly discuss the fact that many neuropsychiatric medications, including: antipsychotics, antidepressants, and mood stabilizers –induce weight gain. 2013 Jul;84(7):796-9. Moreover, lamotrigine users were satisfied with the medication and reported no significant unwanted side effects. Guerdjikova, McElroy, Welge, et al. 2013: Weight change associated with antiepileptic drugs. Among persons who are prone to experiencing weight loss on Lamictal, research indicates that average weight loss ranges from: 2.58 lbs. The effect of Lamictal on weight has been studied quite a bit and various clinical trials have found a minimal impact gain. Researchers concluded that lamotrigine’s effect on body weight is analogous to that of a placebo. A. Researchers assessed the data to determine whether lamotrigine was safe, effective, and tolerable among individuals with bipolar diagnoses. Others affect your energy level. lamotrigine for about 12yrs with no side effects except weight gain, after 8yrs fit free I had a seizure. Meanwhile, a 2006 study comparing the effects on weight of Lamictal, lithium, and a placebo found that obese patients taking Lamictal lost an average of four pounds, while non-obese patients' weight remained essentially the same., Weight gain from drugs used to treat bipolar disorder is unfortunately pretty common. Participants were randomized to receive either lamotrigine (26) or a placebo (25) for a 16-week duration in a double-blind, flexible-dose trial. A. It was further stated that 12.1% of lamotrigine recipients exhibited clinically significant weight loss as a result of treatment. After you began taking Lamictal, how long did it take for you to notice a change in body weight? In the trials, a total of 227 patients received lamotrigine, 166 received lithium, and 190 received a placebo. Lamictal®, also sometimes known by the more generic name lamotrigine, is typically prescribed for seizure patients and people suffering from bipolar disorder. 2006: Impact of lamotrigine and lithium on weight in obese and nonobese patients with bipolar I disorder. Get Lamictal Coupon Card by print, email or text and save up to 75% off Lamictal at the pharmacy. Subscribe now in to enjoy this feature. 1. evaluated the effect of lamotrigine on body weight among persons diagnosed with bipolar 1 disorder. 2006;67(2):258–262. I had a short time on half dose and the increase in mood swings and loss of emotional control returned BIG time. However, cases have occurred in the absence of these factors [see Boxed Warning]. Celexa (Citalopram) vs. Lexapro (Escitalopram): Which Is Better? If you gained weight while using Lamictal, you may experience some weight loss in withdrawal. (What You Should Know), Lamictal Side Effects & Adverse Reactions, Pantoprazole (Protonix) vs. Omeprazole (Prilosec), Lexapro (Escitalopram) vs. Prozac (Fluoxetine), Pregabalin (Lyrica) vs. Gabapentin (Neurontin). Most bipolar drugs cause weight gain rather than weight loss. Lamotrigine is a member of the sodium channel blocking class of antiepileptic medications, yet it is enigmatic in that its exact method of action is not known. (0.6 kg) with placebo. The most weight gain reported in a clinical trial participant receiving Lamictal was ~2.2 lbs. This medication gives me a sense of balance and curbs the extreme shifts, as in rapid cycling. Unexplained weight loss has many causes, medical and nonmedical. This study supports the idea that lamotrigine treatment facilitates weight loss – particularly among those with obesity. That said, it is important to keep in mind that the cause(s) of one person’s weight change on Lamictal might differ from the cause(s) of another’s. Note: The author of this site is not engaged in rendering professional advice or services to the individual reader. There are suggestions, yet to be proven, that the risk of severe, potentially life-threatening rash may be increased by (1) coadministration of LAMICTAL with valproate, (2) exceeding the recommended initial dose of LAMICTAL, or (3) exceeding the recommended dose escalation for LAMICTAL. (0.5 kg) with lamotrigine; weight gain of 2.42 lbs. A total of 51 individuals were recruited to participate in this study, all of whom had met diagnostic criteria for binge eating disorder (in accordance with the DSM). Always talk to your doctor to verify the safety of these weight management strategies before testing. By Guest. 2015;6:242. doi:10.3389/fphar.2015.00242. For this reason, it’s possible that you could be an outlier and end up experiencing significant weight change on Lamictal. Merideth noted that, unlike most mood stabilizers, lamotrigine isn’t associated with weight gain. 2009;24(3):150–158. (1.2 kg) over a 52-week span. Verywell Mind uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. 2004: Safety and tolerability of lamotrigine for bipolar disorder. This is very rare, and can even cause weight gain as well. Marcia Purse is a mental health writer and bipolar disorder advocate who brings strong research skills and personal experiences to her writing. It probably won't affect your weight much at all. Talk to your doctor about your concerns in order to determine if Lamictal is right for you. PRINT. On that basis alone, Lamictal may be a good choice. Researchers then calculated patients’ body weight changes from baseline as a result of antiepileptic use. In fact, some researchers even have looked at the drug as a possible treatment for obesity and as a treatment for binge-eating disorder.. My doctor started me on 25mg for two weeks, with the plan to continue to titrate up. Next post: Lamictal Side Effects & Adverse Reactions, Previous post: Lithium & Weight Gain: How Much? Lamotrigine in the treatment of binge-eating disorder with obesity: a randomized, placebo-controlled monotherapy trial. The body weights of all patients had been recorded prior to antiepileptic treatment, as well as for a period of 3 to 12 months after treatment initiation. A total of 40 individuals were recruited to participate in the trial and randomly assigned to receive either: lamotrigine (200 mg per day) or a placebo – for a 26-week span. I used to eat a lot and now I can barely stomach half a sandwich. Moreover, if you’ve gained or lost weight from Lamictal – what do you think the reasons are for the weight change? The Safety of Using Lamictal During Pregnancy. Milk samples from patients suspected of having severely low blood sugar, lamictal and vyvanse weight loss injecting insulin, and adjusting levels if the respondent completed the survey primarily is intended to be infected even if the. Specifically, researchers sought to determine how lamotrigine impacts weight when administered as a standalone, as well as when administered concurrently with another medication. It is also used off-label as an adjunct in treating clinical depression. lamictal - weight loss or gain? Finally, some antidepressants—specifically, Paxil (paroxetine) and Remeron (mirtazapine)—are associated with weight gain.. The open-label study included a 5-week titration phase with a target dose of lamotrigine set at 200 mg per day. That said, if you are concerned about body weight change while using Lamictal – or have already experienced weight change, below are some weight management strategies to consider implementing. appetite change; faster metabolism; increased energy; etc.). Included below are trials and/or reports in which the effect of Lamictal on body weight was evaluated or discussed. ... black or tarry stool, blood in the stool or urine, rapid weight gain, feeling short of breath or having trouble breathing, irregular heart rhythm or chest pain, dark urine or decreased/stopped urination. Selected from data included with permission and copyrighted by First Databank, Inc. I feel hungry but my stomach is doing some nauseous, crampy thing. Potential and/or hypothetical causes for weight change on Lamictal include: appetite change; gastrointestinal reactions; hormone fluctuations; changes in energy level; altered taste perception; and/or shifts in resting metabolic rate. While Lamictal is regarded as a highly effective anticonvulsant for the management of neurological disorders, and is even classified as an “essential medicine” by the World Health Organization (WHO), some prospective users may be concerned about its side effects – including body weight change – including weight gain and weight loss. Did your weight change occur within a short-term followed by stabilization – or did the weight change occur gradually over a longer-term? Lamictal (lamotrigine) Tablets, Impact of lamotrigine and lithium on weight in obese and nonobese patients with bipolar I disorder, Weight considerations in psychotropic drug prescribing and switching, A single-center, double-blind, placebo-controlled evaluation of lamotrigine in the treatment of obesity in adults. (1.1 kg) with lithium; and weight gain of 1.54 lbs. retrospectively analyzed the impact of lamotrigine treatment on body weight of persons with bipolar disorder. Most evidence suggests that Lamictal has no significant effect on body weight (i.e. doi:10.1097/YIC.0b013e328329c7b5, Prabhavalkar KS, Poovanpallil NB, Bhatt LK. Weight considerations in psychotropic drug prescribing and switching. Assuming you’ve been using other substances with Lamictal – are you sure that those other agents aren’t contributing to your weight change? Though this was a very small-scale study, it supports the idea that Lamictal could cause weight loss of ~2.58 lbs. Unlike most mood stabilizers, though, Lamictal is less likely to cause weight gain. (0.7 kg) with placebo. See below for a comprehensive list of adverse effects. Things you must do . Often, a combination of things results in a general decline in your health and a related weight loss. Average weight changes as a result of lamotrigine administration ranged from -0.38 kg to +1 kg – for an overall average of +0.68 lbs. Blurred vision 2. changes in vision 3. clumsiness or unsteadiness 4. double vision 5. poor coordination 6. skin rash Although lamotrigine (~236 mg/day) and placebo were of similar efficacy in decreasing the weekly number of binge eating episodes and binge days, lamotrigine recipients lost more weight (-1.17 kg) compared to placebo recipients (-0.15 kg). 2009: Lamotrigine in the treatment of binge-eating disorder with obesity: a randomized, placebo-controlled monotherapy trial. You can also subscribe without commenting. (And Why It Happens). I shall not be liable or responsible for any loss or damage allegedly arising from any information or suggestions within this website. Sometimes a specific cause isn't found. Results noted that individuals with obesity exhibited: weight loss of 9.25 lbs. Block, MD, Verywell Mind uses cookies to provide you with a great user experience and for our. How the Atypical Antipsychotic Lurasidone Is Prescribed, Why Celexa and Other SSRIs Can Make You Put on Pounds. (1 kg), and the highest average weight gain in a single trial was 0.68 lbs. Researchers conducted a post-hoc analysis of data from multiple 18-month double-blind, placebo-controlled trials consisting of 155 obese and 399 non-obese patients. Front Pharmacol. Am J Psychiatry. Prescribing Information. conducted a study to investigate the safety and effectiveness of Lamictal for the treatment of binge eating disorder (BED) associated with obesity. Although studies provide averages for how much weight individuals lose or gain throughout trials – they do not account for individual variation. I was prescribed Lamictal for anxiety and bipolar II. Read our, Medically reviewed by Daniel B. (4.2 kg) with lamotrigine treatment; weight gain of 13.44 lbs. This should be reassuring to people with bipolar disorder since so many medications used to treat the condition can cause weight gain. The aforementioned researchers conducted a retrospective observational analysis with electronic primary healthcare records from over 1 million adult patients in Wales – all of whom were over the age of 18 and diagnosed with epilepsy. The National Library of Medicine (NLM), on the NIH campus in Bethesda, Maryland, is the world's largest biomedical library and the developer of electronic information services that delivers data to millions of scientists, health professionals and members of the public around the globe, every day. Understand that your body weight may fluctuate slightly as it readjusts to functioning without the medication. Find reviews for Lamotrigine from other patients. Lamictal is an anticonvulsant medication that can be used to treat seizure disorders, such as epilepsy. Journal of Neurology, Neurosurgery, and Psychiatry. Results indicated that lamotrigine recipients exhibited no significant change in body weight; weight remained stable throughout the 18 months. Everyone participating in the study had a body mass index (BMI) of between 30 and 40, which placed them in the obese to the severely obese range. Updated 2005. That said, it was further mentioned that lamotrigine appears to be weight neutral. For the study, researchers conducted a post-hoc analysis of data from a 12-week open-label study comprised of 1175 patients (with bipolar 1 disorder) using lamotrigine to treat symptoms. 2013;125(5):117–129. I was 225 pounds before I got on lamictal and my weight keeps dropping. Management of bipolar depression with lamotrigine: an antiepileptic mood stabilizer. Nevertheless, evidence is based upon average responses to the medication – and does not account for individual variability in reactions. I have been having trouble eating since starting the lamictal. An analysis by researchers determined that, on average, lamotrigine users exhibited an average weight loss of 2.64 lbs. The body weights, BMIs, body fat percentages, serum lipids, and glycosylated hemoglobin levels of participants were recorded at baseline – and compared to measures following week 26. If you ended up experiencing weight loss or weight gain while using Lamictal, document the specific amount of weight change that you experienced in the comments section below. I've been on lamictal for a few months now and have noticed extreme loss in appetite. Save to favs. There are a myriad of possible variables that could influence someone’s likelihood of experiencing weight change while using Lamictal (i.e. (0.31 kg). J Clin Psychiatry. A. Amitriptyline (Elavil) Withdrawal Symptoms + How Long Do They Last? … However, the Lamictal didn't seem to affect other aspects of their binge-eating disorder when compared to placebo. The patients received either: lamotrigine, lithium, or a placebo for the 18-month duration. Other side effects include: infection, dyspepsia, abnormal gait, constipation, and drowsiness. Usually, an unrecognized cancer will have other symptoms or abnormalities of laboratory tests, in addition to unexplained weight loss. Because lamotrigine doesn’t generally cause weight gain, Merideth organized a trial to determine the effectiveness of lamotrigine compared to placebo for the induction of weight loss among adults with obesity. If you're concerned that taking the medication Lamictal (lamotrigine) may cause you to gain weight, there's good news. (And Why It Happens), Fetzima (Levomilnacipran) & Weight Loss vs. Gain, Does Mirena Cause Weight Gain? But few studies have actually looked at how weight loss affects these patients’ long-term health, including their risk of heart disease (the most common … 2007: Effectiveness and weight effects of open-label lamotrigine with and without concomitant psychotropic medications in patients with bipolar I disorder. Cannabidiol (CBD) Side Effects & Adverse Reactions, L-Tyrosine Side Effects & Adverse Reactions (List), Armour Thyroid Side Effects & Adverse Reactions (List), Remeron (Mirtazapine) Withdrawal Symptoms + How Long They Last, Source:, Source:, Source:, Source:, Source:, Source:, Source:, Source: In short, Lamictal users are unlikely to experience weight gain as a result of treatment, and if weight gain occurs, it probably won’t be significant. (e.g. I have recently started taking Lamictal for bipolar, 25mg the first week and am now at 50mg until I see my pdoc next month. Communities > Bipolar Disorder > Lamictal weight loss. Lamictal) users exhibited no significant changes in body weight. Among persons who are prone to experiencing weight loss on Lamictal, research indicates that average weight loss ranges from: 2.58 lbs. The weight loss is a side affect because it can disrupt hormone balance. Ness-Abramof and Apovian published a paper discussing drug-induced weight gain. Through the aforementioned mechanisms of action, Lamictal effectively prevents seizures and stabilizes mood. Does My Friend or Loved One Have an Eating Disorder? to 9.25 lbs. Weight Gain and Other Bipolar Medications, How to Take Lamictal If You Have Bipolar Disorder. Hello, I am a 22 year old male 6 ft 3 190 pounds. doi:10.1176/appi.ajp.163.7.1199, Hasnain M, Vieweg WV. Therefore, if you're already overweight, you and your psychiatrist may want to consider the possibility of additional weight gain in determining your medication regimen for your bipolar disorder. Thank you, {{}}, for signing up. Pickrell, Lacey, Thomas, et al. Average change in body weight from baseline was -6.4 lbs. Symptoms of Lamictal overdose can include rapid, uncontrollable eye movements, clumsiness and lack of coordination affecting your balance, impaired or loss of consciousness, fits or coma. The side-effects profile varies for different patient populations. Research suggests that Lamictal modifies neurochemistry by: inhibiting voltage-gated sodium channels, blocking various calcium channels (L-type; N-type; P-type), antagonizing sigma and 5-HT3 receptors, upregulating GABA signaling, and suppressing the release of glutamate and aspartate. HIV testing and submission to NHSN during 2018 to May 21, 2020. The most commonly observed (≥5% for LAMICTAL and more common on drug than placebo) adverse reactions seen in association with the use of LAMICTAL during the monotherapy phase of the controlled trial in adults not seen at an equivalent rate in the control group were vomiting, coordination abnormality, dyspepsia, nausea, dizziness, rhinitis, anxiety, insomnia, infection, pain, … Bowden CL, Calabrese JR, Ketter TA, Sachs GS, White RL, Thompson TR. U.S. Food & Drug Administration. Weight loss is found among people who take Lamictal, especially for people who are female, 40-49 old, have been taking the drug for 2 - 5 years. Impact of lamotrigine and lithium on weight in obese and nonobese patients with bipolar I disorder.