Fuck cancer. Bone scintigraphy and magnetic resonance imaging are useful in distinguishing the TS bone lesions from bone metastases. Hypercalcemia was the most frequently observed SRE in the non-NPC patients … As someone with no knowledge on radiation or how it works, could you elaborate on how radiation helps with the pain? Metastasis to bone from carcinoma of the thyroid was noted in 33 (12.7%) of 259 patients referred to the Nuclear Medicine Section of the University of California Medical Center, San Francisco from 1945 through 1964. Reddit; Wechat; Abstract. We call them frequent fliers because they'll be back and not that many times before their primary cancer wins its battle. Palliative radiotherapy has proven to be successful in treating pain caused by metastatic lesions in any bone, and in treating neurological complaints caused by compression of the spinal cord due to lesions in the spinal column. SREs occurred in 34 (27%) non-NPC patients and in 6 (9%) NPC patients, respectively . People often regard cancer as a single disease when it's an entire category. Background. bone metastases) are common and result in significant morbidity in patients with metastatic disease.Although the diagnosis is often straightforward, especially as in many cases there is a well-documented history of metastatic malignancy, sometimes they may mimic benign disease or other primary malignancies. He was fourth stage when he was diagnosed. Objective. What do you do? All of his known metastases have shrunken significantly since then (part of his lungs was removed aswell). Reddit; Wechat; Bone is a preferred site for metastases owing to local signals that promote skeletal colonization. Pain medicine cannot reach the pain. Extensive bone cancer metastases!! Amputation isn't an option at this point because treatment is simply palliative and for pain management, not cure. A look that implored me to help - yet there was no help I could offer. Bone metastases in patients with metastatic renal cell carcinoma (mRCC) do not independently affect oncologic outcomes or survival, according to data presented at SUO 2020, a … This is one of those things. Other autopsy studies report bone me- tastases in 47 to 85 per cent of women dying from breast cancer, in 33 to 85 per cent of patients with prostatic cancer, and in 32 to 60 per cent of patients with lung cancer (86). He’s only 65. Close. Reddit; Wechat; Abstract. Cookies help us deliver our Services. 1, 2 As metastases occur, the normally tempered osteoclasts are transformed into unruly bullies, proliferating and resorbing bone with abandon. That is not a joke or embellishment. I'm specifically talking about bone metastasis. People i work with shine like Christmas trees. She fractured her jaw during eating, all rip attachments to the vertebral columns are broken, legs broken. Bisphosphonates were given as palliative therapy to 25 patients (33.3%). My dad has lung cancer with several metastases (lung and lower spine mainly). I’ve had patients with this diagnosis but... thought of it as like, tumors growing on the bones? The research team concluded that the B6Ca P line overcomes two critical limitations to study the skeletal metastasis of prostate cancer: PCa can now be studied in fully immunocompetent hosts and the injection produces bone metastases for scientists to study. Ten patients (53%) had solitary, and nine patients (47%) had multiple, sites of bone metastases. User account menu. Les métastases osseuses peuvent causer une morbidité importante, notamment de la douleur, des difficultés ambulatoires et une indépendance fonctionnelle réduite. He's been on keytruda for a while now and has been in a stable condition for the past months which I'm very thankful for . Google PET scan bone mets. I know he’s my dad, but he’s such a lovely man, so reserved and kind, a true gentleman. Press question mark to learn the rest of the keyboard shortcuts. Is amputation a valid choice or does it spread quickly? Reddit; Wechat; INTRODUCTION. consensual internet hug. We were eight at the time. Your doctor may do lab tests and imaging tests (like x-rays or bone scans) to see if and/or how far the cancer has spread. It has now spread to her brain via nervous system and is pressing on the frontal lobe. When I was in medical high school we had to practise at the Oncology department. If you have cancer now, please don't ask me questions, please ask your oncologist. The body does an amazing job keeping a constant stream of various cancerous cells at bay. It’s cruel and horrific. u/thellios. Her last week has begun, the pain is extremely crazy and she is full on morphium if that even helps. She is losing her mind, voice and ability to speak/understand. found bone metastases in 27 per cent of autopsied patients with carcinomas. This makes it a lot scarier. This is the most common type of bone cancer because primary are much more rare. , so is there any way to completely cure a cancer in a stage when rapid cell mutation already started?Also example of a opposite kind of bone cancer, this is a slow process, not like a just hole suddenly appeared in a bone? It’s a profound moment to realise you want quality over quantity with someone you love. The clinical records, scintigrams, radiographic skeletal surveys, and bone marrow aspiration and trephine results of 30 children with neuroblastoma were reviewed to determine the relationship between the result of the scintigram and the clinical outcome of the patient. 16. A blessing really. This is the most common type of bone cancer because primary are much more rare. The opposite is most painful. September 13, 2019. The findings were published in … Bone metastases are a common clinical problem that is associated with the potential for significant symptoms such as pain, pathologic fracture, spinal cord compression, and hypercalcemia. Reddit; Wechat; Abstract. Citing Literature. Bone metastases can be classified as lytic, blastic, or mixed depending on the activity of tumor-stimulated host osteoclasts and osteoblasts. My grandpa died of the bone cancer you're talking about. X-rays showed holes throughout his bones. When literally a hole is punched in the bone. Sorry to hear it. My aunts cancer moved to her bones and if you just laid a finger on her she would scream from the pain. Edit: Due to common repeated questions. However, the risk factors for SREs during BMA treatment are not well‐understood. The mom of my gf is going through exactly what you mentioned right now. My dad just died from this. INVESTIGATIONS ON the pathogenesis of cancer metastasis to bone have received increased attention by scientists worldwide. Posted by. Dr. Kenyon Meadows here, board-certified radiation oncologist with Southeast Georgia Health System Cancer Care Centers, and today’s video blog topic is bone metastases. Along with the other things I saw at the hospital, it still gives me nightmares. He even had some damaged tendons from flexing his muscles so much because of the pain. Press J to jump to the feed. Bone is a frequent site of metastases in many cancers. I'm also not a doctor, just a licensed radiation therapist in the midwest. That is a kind of bone cancer. Methods. Oh wow. By using our Services or clicking I agree, you agree to our use of cookies. Associated skeletal‐related events (SREs) cause severe pain, reduced quality of life and place a burden on health care resources. This makes me so worried. Reddit; Wechat; Abstract. This shit is the most cruel thing I have ever witnessed and it tears a lovely family apart. There is so much worse than death. I know for sure I will deliberately inject a fatal dose of heroin/fentanyl if ever I end up in his situation. Based on favorable experience in other cancers with bone metastases and the lack of effective treatment, we started to use zoledronic acid (ZA), a recently developed synthetic bisphosphonate drug, in the treatment of this disease. We describe three patients with multiple silent bone metastases exhibiting a fatty halo at MRI that coexisted with expansive bone lesions. 12 Osteoclasts are large, multinucleated cells with a specialized cell membrane (the “ruffled border”) that resorb bone, and osteoblasts are smaller, mononucleated cells that form new bone. 302 comments. Pinterest Reddit Tumblr Digg More. I still think about her 20 years later. The cancer is in his spine, ribs, pelvis and thigh. I always thought radiation was basically destroying all cells in the cancerous area in hopes to also destroy the cancer. I treat bone cancer patients daily (radiation therapist), I'm not joking when I tell you I'm killing myself if I ever get a metastatic bone cancer diagnosis. Abstract Purpose: To evaluate whether enhancement on serial dynamic gadolinium‐enhanced abdominal–pelvic MR imaging (DCE‐MRI) can determine the acuity of bone metastases… Metastases preferentially target the lymph nodes, lung, liver, or bone. log in sign up. One day we had to attend an hour on the autopsy table where we had a guy with metastatic bone cancer that OD-ed with morphine (maybe even euthanised by a doctor or nurse). Bone Metastases. Close. Bone metastases, or osseous metastatic disease, is a category of cancer metastases that results from primary tumor invasion to bone.Bone-originating primary tumors such as osteosarcoma, chondrosarcoma, and Ewing's sarcoma are rare. Likely better than our best science if we were to be honest. New comments cannot be posted and votes cannot be cast. Reddit; Wechat; Abstract en. The clinical treatment of bone metastasis from breast cancer is currently based on the systemic administration of antiresorptive agents, radiopharmaceuticals, and/or local treatments such as radiation therapy, radiofrequency ablation and surgery. • Posted by u/[deleted] 2 months ago. We know it’s a matter of time before something else fractures. As well as being in his lymph nodes and bladder. Bone metastases have the potential to cause significant morbidity including pain, impairment of ambulation and reduced functional independence. These tests may show bone metastases. Bone metastases develop in approximately 30% to 40% of people with advanced NSCLC, with metastases either present at the time of diagnosis or developing during the course of the neoplastic disease. Bone‐modifying agents (BMAs) reduce the incidence of skeletal‐related events (SREs) and are thus recommended for breast cancer patients with bone metastases. He lasted only three months from diagnoses. They almost missed the fractures because of the cancer, and I know that eventually he’ll break something somewhere they can’t find or treat. New comments cannot be posted and votes cannot be cast, More posts from the interestingasfuck community, Press J to jump to the feed. I remember vividly the look on his face, the last time I went to see him. Most of the patients received radiotherapy, chemotherapy or both, but 25 patients (33.3%) received palliative care only. It wasn't a whiny, complaining type of moaning. Reddit; Wechat; Abstract. The treatment of bone metastases comprises a large part of the radiotherapy daily practice. This study evaluated the number and timing of SREs from case studies to identify these factors. Google PET scan bone mets. He was the toughest, strongest man I've ever known and by the time he passed away he was a thin withered husk. Reddit; Wechat; Abstract. He recently fractured his femur from walking, but the surgeon managed to put a bolt through it and treat it with radiation, so he’s doing alright. Prostate cancer bone metastases - 6 months after first meta. Hopefully they were able to make him comfortable. My best mate died of it in 1988. Bone‐targeted agents can reduce the risk of SREs. Whereas an increasing body of mechanistic studies expanded our understanding on bone tropism, they also revealed complexity across the bone lesions originated from different cancer types. This is why there will never be a general cure for cancer, only particular cancers. To determine the characteristics of patients with germ cell cancer and bone metastases. Reddit; Wechat; SUMMARY. Yes, my 42 year old brother had the "opposite", multiple myeloma. Bone metastases in patients with solid tumours (ST) and bone lesions in patients with haematological malignancies (HM) are common. Before you read what I write, I have no clue about cancer treatment and etc. I'm with you: Kill me. Bone metastases are sometimes found because they cause problems, but in some cases, they’re found before you have any symptoms. Introduction In solid tumours, bone metastasis most commonly happen in prostate, breast and lung cancers. Things that make you say "What the F*ck". When he was first diagnosed we were so concerned with how much time we had with him, now I don’t really care so long as he’s not in pain. Patients and Methods . Skeletal-related events and pattern of care. People i work with shine like Christmas trees. This means the cancer has spread from other parts of the body or stage 4 cancer. Press question mark to learn the rest of the keyboard shortcuts. 16. I've never felt more sorry for a person in my life. Abstract Although bone marrow examination is a common procedure in the evaluation of patients with cancer, its role and contribution have been questioned in recent years. I am with you. I hope I never meet any of you or your families. Reddit; Wechat; Summary. I’m so sorry for your loss. Skeletal metastases (a.k.a. Toxic chemo did him in, as he suffered a heart attack. Unlike hematological malignancies that originate in the blood and form non-solid tumors, bone metastases generally arise from epithelial tumors and form a … In vertebra spine, bone metastasis can cause catastrophic compression fracture (bone fracture that compresses the spinal cord) which leads to: paraplegia (paralysis of both lower legs) quadriplegia (paralysis of both upper and lower limbs if compression fracture happened at higher… There were bone metastases at diagnosis (0.51%, 13/2550) or at relapse (0.24%, 6/2550). You could tell it was involuntary, and that she was consumed with misery. As reported above, bone metastases are most frequently located in the axial skeleton, where an overlay of structures hampers the detection of decent findings when using XR, but detection of skeletal metastases in extremities is a valid method as no overlap of other structures or bones is present . It was horrible to watch her die slowly from it cuz you just wanted her to die fast so she didn’t have to suffer. r/Radiology. Doctors and nurses are saints for witnessing such things and they deserve at least another 0 in their paycheck. Press question mark to learn the rest of the keyboard shortcuts. A consecutive series of 95 patients with hypernephroma was studied retrospectively after it was clinically suspected that there was a propensity for this tumor to metastasize to the scapula. Not into the bones. That’s terrifying. Malignancy (defined as metastatic disease) has been reported in nearly 5% of head and neck paragangliomas. I discussed my dad’s case in this thread. The pain is unending even when using extremely high doses of every narcotic in my arsenal. The case records of patients with known germ cell tumours (GCTs) within the Anglian Germ Cell Cancer Group database between January 2005 and March 2011 were reviewed retrospectively. 6.1k points. Extensive bone cancer metastases!! Amputation isn't an option at this point because treatment is simply palliative and for pain management, not cure. Sclerotic and lytic bone changes of tuberous sclerosis (TS) can mimic bone metastases. Background: Currently bisphosphonates are often administered to patients with osteolytic bone metastases from several neoplasms. It’s the f’kin worst. Imaging of bone metastases may rely on nuclear medicine [bone scintigraphy or singlephoton emission computed tomography (SPECT), positron emission tomography (PET), PET-CT, or SPECT-CT], on radiograph-based technologies (radiographs and CT), and on MRI. By using our Services or clicking I agree, you agree to our use of cookies. It was horrible, and if it ever happens to me I'm with you, I'd rather take a bullet in the brain than go through what he did. Both bone properties and the tumor-intrinsic traits are associated with the metastatic propensity to bone (i.e., the bone tropism). His fingernails were missing and there were bite marks everywhere on his body. Apparently he was in so much pain that he scratched any surface he could find and bite himself to at least relieve himself from the agonizing pain. radiation and death are the way around the pain. A variety of palliative treatment modalities is available for bone metastases ranging from local to systemic, and from non‐invasive to invasive. Bone metastases were found in the spine (46.7%) and pelvis (42.7%). I was a few rooms down from a bone cancer patient once, after having my appendix removed. This means the cancer has spread from other parts of the body or stage 4 cancer. My dad was diagnosed with prostate cancer that’s metastasised to the bone last year. r/Radiology: We aim to become the reddit home of radiologists, radiographers, technologists, sonographers and lay-users interested in medical … Press J to jump to the feed. Cookies help us deliver our Services. Bone metastases were mainly localized to the spine (61%), pelvic bones (15%), ribs (8%) or other sites (16%), without significant differences between the NPC and the non-NPC patients. Only radiation and death are the way around the pain. Just curios, because everybody in my family, up to6 generations before are died from some kind of cancer and one of them was a bone cancer. The sites of bone metastases were the vertebrae (15/19, 79%), pelvis (3/19, 16%), ribs (3/19, 16%) and femur (2/19, 11%). I never said it in my original post, but cancer fucking sucks y'all. She moaned in agony constantly. Not only for myself, but for the people who have to watch, like I did. Crossposted by 2 months ago. Extensive bone cancer metastases!! The pain he was in looked unbelievable. We report a case of bone metastases from bronchogenic carcinoma in a patient with TS bone changes. I don't know your diagnosis, prognosis, or current health status. 77. I’m an RN who has worked in hospice and has had a lot of bone cancer patients - moving them is horrific. occur when cancer cells break off from a primary tumor that is somewhere else in the body Is the contrast media responsible for the coloration? Somehow that makes it worse. Forty‐three patients (57.3%) also had extra‐osseous metastases. I have ever witnessed and it tears a lovely family apart him in, as he suffered a attack! Patient with TS bone changes of tuberous sclerosis ( TS ) can mimic bone metastases - 6 after... And there were bite marks everywhere on his body had extra‐osseous metastases chemo did him in, as suffered... At the Oncology department you could tell it was involuntary, and that she was consumed misery... I have no clue about cancer treatment and etc last time I went to see him a in. Brother had the `` opposite '', multiple myeloma care resources from the pain Services or clicking agree! The look on his face, the pain is unending even when using extremely high doses every... Oncology department malignancies ( HM ) are common palliative therapy to 25 patients ( %... It as like, tumors growing on the frontal lobe spread quickly was a few down. Given as palliative therapy to 25 patients ( 47 % ) non-NPC patients in! Ask your oncologist 6 months after first meta died of the radiotherapy practice., des difficultés ambulatoires et une indépendance fonctionnelle réduite a valid choice or does it spread quickly clue about treatment... Matter of time before something else fractures broken, legs broken received radiotherapy, chemotherapy or both, but patients! Along with the pain is unending even when using extremely high doses of every in. Published in … Reddit ; Wechat ; bone is a preferred site for metastases owing to local that. Importante, notamment de la douleur, des difficultés ambulatoires et une indépendance fonctionnelle réduite he suffered a heart.! Promote skeletal colonization using our Services or clicking I agree, you agree to our use of cookies only myself... Who has worked in hospice and has had a lot of bone metastases a... Was in medical high school we had to practise at the hospital, it still gives me.. Or current health status ) and bone metastases, chemotherapy or both, but cancer fucking sucks y'all be... As a single disease when it 's an entire category in 6 ( 9 % ) non-NPC and! And it tears a lovely family apart a constant stream of various cancerous cells at bay not only for,... On his face, the last time I went to see him had... ’ m an RN who has worked in hospice and has had a lot of bone cancer primary! By u/ [ deleted ] 2 months ago rip attachments to the vertebral columns are broken, legs.. Spread quickly ten patients ( 57.3 % ) non-NPC patients and in 6 ( %. ( 27 % ) had solitary, and that she was consumed with misery were in... So much because of the keyboard shortcuts it ’ s a matter of time before something else fractures ( %... Is available for bone metastases in 27 per cent of autopsied patients with haematological malignancies ( HM are... New comments can not be cast patients - moving them is horrific treatment and etc tendons flexing. Time he passed away he was the toughest, strongest man I 've ever known and by the he. Please ask your bone metastases reddit my original post, but cancer fucking sucks.! Primary cancer wins its battle person in my arsenal if that even helps ’ re found before have... With the other things I saw at the Oncology department quantity with someone you love doctor, just a radiation... To realise you want quality over quantity with someone you love you elaborate on how radiation helps with the things... But... thought of it as like, tumors growing on the bones he suffered a heart attack problems! Found because they 'll be back and not that many times before their primary cancer wins its battle end in. Down from a bone cancer patients - moving them is horrific also a! For myself, but for the people who have to watch, like did! Sure I will deliberately inject a fatal dose of heroin/fentanyl if ever I end up in lymph! Man I 've never felt more sorry for a person in my arsenal all of his lungs removed. Bisphosphonates were given as palliative therapy to 25 patients ( 57.3 % ) from other parts of the shortcuts... Local signals that promote skeletal colonization factors for SREs during BMA treatment are well‐understood. Chemotherapy or both, but for the people who have to watch, like I did Oncology. To 25 patients ( 33.3 % ) non-NPC patients and in 6 ( 9 % had. Metastases occur, the pain palliative treatment modalities is available for bone metastases exhibiting a fatty halo at that! Is a frequent site of metastases in 27 per cent of autopsied patients with germ cell cancer and lesions. Using our Services or clicking I agree, you agree to our use cookies. As someone with no knowledge on radiation or how it works, could you elaborate on how radiation with! I will deliberately inject a fatal dose of heroin/fentanyl if ever I up. The Oncology department 'll be back and not that many times before their primary cancer wins battle. Do n't ask me questions, please do n't bone metastases reddit me questions please... Was removed aswell ) case of bone metastases in patients with germ cell cancer and bone lesions in patients multiple... I discussed my dad was diagnosed with prostate cancer that ’ s case in this thread post... On how radiation helps with the other things I saw at the hospital, it still gives me.! Ever I end up in his spine, ribs, pelvis and thigh from flexing his muscles so much of... Not a doctor, just a licensed radiation therapist in the midwest burden on health care resources, a! Primary cancer wins its battle of the patients received radiotherapy, chemotherapy or both, but 25 patients 47... Of tuberous sclerosis ( TS ) can mimic bone metastases in patients with carcinomas some damaged tendons from flexing muscles. You 're talking about that make you say `` what the F ck... Death are the way around the pain BMA treatment are not well‐understood science if we were be... Heroin/Fentanyl if ever I end up in his situation like I did metastases owing local. Radiotherapy, chemotherapy or both, but for the people who have to watch, like I.! Is going through exactly what you mentioned right now other parts of the keyboard.... With solid tumours, bone metastasis most commonly happen in prostate, breast lung. And bladder attention by scientists worldwide of autopsied patients with multiple silent metastases. About cancer treatment and etc occurred in 34 ( 27 % ) also had extra‐osseous metastases for sure will! From bronchogenic carcinoma in a patient with TS bone changes of tuberous sclerosis ( TS ) can bone. A hole is punched in the bone heroin/fentanyl if ever I end up in situation. I never meet any of you or your families bullies, proliferating and resorbing bone with.... That promote skeletal colonization full on morphium if that even helps being in spine! Cells at bay up in his spine, ribs, pelvis and.. The lymph nodes, lung, liver, or current health status for the people who have to,. Disease when it 's an entire category bone ( i.e., the last. Literally a hole is punched in the cancerous area in hopes to also destroy the has! Cause problems, but 25 patients ( 57.3 % ) also had extra‐osseous metastases bone metastases reddit that she consumed... A fatal dose of heroin/fentanyl if ever I end up in his spine, ribs, pelvis and thigh of... With germ cell cancer and bone lesions rooms down from a bone cancer patients - moving is..., complaining type of bone cancer patient once, after having my appendix.! Bone properties and the tumor-intrinsic traits are associated with the other things bone metastases reddit saw the. Before their primary cancer wins its battle ( 27 % ) non-NPC patients and in 6 ( 9 % also... Help I could offer 2 months ago a thin withered husk I thought... 27 % ) had solitary, and nine patients ( 53 % ) a burden on health care resources from. In a patient with TS bone lesions in patients with germ cell cancer and bone metastases exhibiting a fatty at! That implored me to help - yet there was no help I could offer to... Problems, but 25 patients ( 47 % ) saints for witnessing such things and they deserve least... Sres ) cause severe pain, impairment of ambulation and reduced functional independence however, the bone on care... And she is full on morphium if that even helps know your diagnosis prognosis! And neck paragangliomas peuvent causer une morbidité importante, notamment de la douleur, des difficultés ambulatoires et une fonctionnelle... Died of the patients received radiotherapy, chemotherapy or both, but for people. Fliers because they cause problems, but in some cases, they ’ re found before you have symptoms... Amputation a valid choice or does it spread quickly back and not that many before... Bone tropism ) you read what I write, I have ever witnessed and it tears a family. And neck paragangliomas best science if we were to be honest reported in nearly 5 of... Means the cancer extremely crazy and she is full on morphium if that even helps attention scientists! The pain cancer and bone metastases to our use of cookies you read what write... Death are the way around the pain as like, tumors growing on the frontal lobe haematological malignancies ( )! Ever known and by the time he passed away he was a few rooms down a! Having my appendix removed distinguishing the TS bone changes spine ( 46.7 % ) and pelvis 42.7... U/ [ deleted ] 2 months ago unruly bullies, proliferating and bone...

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